Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome
Autor: | Fernando Monteforte, Ramona Morariu, Francesco Logullo, Lucia Pettinari, Maria Giovanna Danieli |
---|---|
Rok vydání: | 2012 |
Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty Ataxia medicine.diagnostic_test business.industry Immunology Sensory system Azathioprine Magnetic resonance imaging Case Report Mycophenolate Gastroenterology Hyperintensity Surgery Refractory Internal medicine medicine Immunology and Allergy medicine.symptom business lcsh:RC581-607 Burning Sensation medicine.drug |
Zdroj: | Case Reports in Immunology Case Reports in Immunology, Vol 2012 (2012) |
ISSN: | 2090-6609 |
Popis: | Sensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy. |
Databáze: | OpenAIRE |
Externí odkaz: |