Cobalt Catalysis for Enantioselective Cyclobutanone Construction
| Autor: | Vy M. Dong, Daniel K. Kim, Raphael S. Kim, Jan Riedel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
inorganic chemicals
chemistry.chemical_element Hydroacylation Stereoisomerism 010402 general chemistry 01 natural sciences Biochemistry Catalysis Article chemistry.chemical_compound Colloid and Surface Chemistry Molecule Organic chemistry Molecular Structure 010405 organic chemistry Enantioselective synthesis Cyclobutanone General Chemistry Cobalt 0104 chemical sciences chemistry Intramolecular force Chemical Sciences Cyclobutanes |
| Zdroj: | Journal of the American Chemical Society, vol 139, iss 30 |
| ISSN: | 1520-5126 |
| Popis: | Over the past forty years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth abundant cobalt salts that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol% catalyst loading and as low as 50 °C). |
| Databáze: | OpenAIRE |
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