Vascular endothelial growth factor‐loaded poly‐lactic‐co‐glycolic acid nanoparticles with controlled release protect the dopaminergic neurons in Parkinson's rats

Autor:	Afsar Khan, Hao Song, Qian‐Ru Sun, Xian‐Yue Meng, Li Zhang, An‐Qi Huang, Jun Han, Yudan Wang, Xiao‐Qian Sun, Xue‐Li Li
Rok vydání:	2020
Předmět:	Male Parkinson's disease Drug Compounding VEGF receptors Pharmacology 01 natural sciences Biochemistry Neuroprotection Rats Sprague-Dawley Lesion chemistry.chemical_compound Nanocapsules Polylactic Acid-Polyglycolic Acid Copolymer Drug Discovery medicine Animals Humans Glycolic acid biology Vascular Endothelial Growth Factors 010405 organic chemistry Chemistry Dopaminergic Neurons Organic Chemistry Dopaminergic Biological Transport Parkinson Disease medicine.disease Controlled release 0104 chemical sciences Vascular endothelial growth factor Drug Liberation 010404 medicinal & biomolecular chemistry Neuroprotective Agents Blood-Brain Barrier Delayed-Action Preparations Models Animal biology.protein Molecular Medicine medicine.symptom Behavior Observation Techniques
Zdroj:	Chemical Biology & Drug Design. 95:631-639
ISSN:	1747-0285 1747-0277
DOI:	10.1111/cbdd.13681
Popis:	Vascular endothelial growth factor (VEGF) had neuroprotective effects on dopaminergic (DA) neurons. In order to overcome the gastrointestinal digestion and bioaccessibility, VEGF was encapsulated with poly-lactic-co-glycolic acid nanospheres (NS) in order to prevent the VEGF degradation until its release. The caudal administration of VEGF and NS encapsulated VEGF at different doses (1.0, 10.0, and 100.0 ng/ml) on the rats with Parkinson's disease lesion was evaluated. Intravenous injected VEGF at the dose of 1 ng/ml displayed the strongest neuroprotective effect than other groups as well as the stereotaxic group. The NS encapsulated with VEGF can pass through blood-brain barrier and protect the DA neurons. There was no significant difference between intravenous injection method and stereotaxic method, while the first method is simpler and convenient. Injection of NS encapsulated with VEGF may become a valuable neurorescuing therapeutic approach for Parkinson's disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611e43e71e13ac511fd58d2d8d336e03 https://doi.org/10.1111/cbdd.13681 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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