Case of Polymorphic Ventricular Tachycardia in Diphenhydramine Poisoning

Autor:	Ajay K. Joshi, Hassan Borghei, Tatjana Sljapic, Peter R. Kowey
Rok vydání:	2004
Předmět:	Adult medicine.medical_specialty medicine.medical_treatment Population Electric Countershock Suicide Attempted Torsades de pointes Cardioversion Ventricular tachycardia QT interval Electrocardiography Torsades de Pointes Physiology (medical) Internal medicine Intensive care Anti-Allergic Agents medicine Humans education Proarrhythmia education.field_of_study business.industry Diphenhydramine Recovery of Function medicine.disease Anesthesia Cardiology Drug Overdose Cardiology and Cardiovascular Medicine business medicine.drug
Zdroj:	Journal of Cardiovascular Electrophysiology. 15:591-593
ISSN:	1045-3873
DOI:	10.1046/j.1540-8167.2004.03173.x
Popis:	This is the first reported case of torsades de pointes attributable to diphenhydramine, a drug with weak I(Kr) effects. A 26-year-old, healthy man was admitted to intensive care after a diphenhydramine overdose. Results of physical examination, ECG, and electrolytes were normal at admission. Despite supportive care, he developed typical, sustained, torsades de pointes with a markedly prolonged QT interval requiring cardioversion. Drugs with weak I(Kr)-blocking effects may cause lethal proarrhythmia in susceptible individuals when delivered in high concentrations. This case illustrates the variation in repolarization reserve that exists in a free-standing population.
Databáze:	OpenAIRE
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