Effects of 2-Nicotinamidoethyl Nitrate (SG-75) on Dog Coronary Artery and Cat Papillary Muscle
| Autor: | Matao Sakanashi, Yutaka Horio, Haruo Araki, Fumio Takenaka |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Niacinamide medicine.medical_specialty Contraction (grammar) Potassium chemistry.chemical_element Stimulation Calcium Calcium Chloride Nitroglycerin Dogs 2-Nicotinamidoethyl Nitrate Internal medicine medicine Animals Papillary muscle Nitrates CATS Isoproterenol Papillary Muscles Coronary Vessels Electric Stimulation medicine.anatomical_structure chemistry Cats Cardiology Female Cardiology and Cardiovascular Medicine Muscle Contraction Artery |
| Zdroj: | Japanese Heart Journal. 20:549-556 |
| ISSN: | 1348-673X 0021-4868 |
| DOI: | 10.1536/ihj.20.549 |
| Popis: | Effects of 2-nicotinamidoethyl nitrate (SG-75) on isolated dog coronary artery and cat papillary muscle were investigated. SG-75 dose-dependently relaxed the isolated coronary arterial strips contracted with potassium. Large doses of SG-75 depressed contraction of papillary muscle driven with electrical stimulation and inhibited enhancement of contraction of papillary muscle induced by calcium and isoproterenol. From these results it is suggested that SG-75 may have a weak Ca++-antagonistic action. |
| Databáze: | OpenAIRE |
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