Ubiquitin-related processes and innate immunity in C. elegans
| Autor: | Jonathan J. Ewbank, Orane Visvikis, Juan A. Garcia-Sanchez |
|---|---|
| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), ANR-16-CE15-0001,ELEGINN,Analyse intégrée de l'immunité innée antifongique chez C. elegans(2016) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Innate immune system biology ved/biology Effector Host–pathogen interaction [SDV]Life Sciences [q-bio] ved/biology.organism_classification_rank.species SUMO protein Ubiquitination Cell Biology Computational biology SUMOylation Host-Pathogen Interaction Cellular and Molecular Neuroscience Immune system Proteostasis Ubiquitin biology.protein Unfolded Protein Response Molecular Medicine Model organism Molecular Biology ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Cellular and Molecular Life Sciences Cellular and Molecular Life Sciences, 2021, 78 (9), pp.4305-4333. ⟨10.1007/s00018-021-03787-w⟩ Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (9), pp.4305-4333. ⟨10.1007/s00018-021-03787-w⟩ |
| ISSN: | 1420-682X 1420-9071 |
| Popis: | International audience; Innate immunity is an evolutionary ancient defence strategy that serves to eliminate infectious 19 agents while maintaining host health. It involves a complex network of sensors, signaling proteins 20 and immune effectors that detect the danger, then relay and execute the immune programme. Post-21 translational modifications relying on conserved ubiquitin and ubiquitin-like proteins are an integral 22 part of the system. Studies using invertebrate models of infection, such as the nematode 23 Caenorhabditis elegans, have greatly contributed to our understanding of how ubiquitin-related 24 processes act in immune sensing, regulate immune signaling pathways, and participate to host 25 defence responses. This review highlights the interest of working with a genetically tractable model 26 organism and illustrates how C. elegans has been used to identify ubiquitin-dependent immune 27 mechanisms, discover novel ubiquitin-based resistance strategies that mediate pathogen clearance, 28 and unravel the role of ubiquitin-related processes in tolerance, preserving host fitness during 29 pathogen attack. Special emphasis is placed on processes that are conserved in mammals. |
| Databáze: | OpenAIRE |
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