Coaxial Electrospray Formulations for Improving Oral Absorption of a Poorly Water-Soluble Drug
| Autor: | Shinji Sakuma, Shinji Yamashita, Marina Yamamoto, Kohsaku Kawakami, Yoshie Masaoka, Makoto Kataoka, Shaoling Zhang |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Chromatography Calorimetry Differential Scanning Chemistry Chemistry Pharmaceutical Dispersity Administration Oral Pharmaceutical Science Methacrylate Griseofulvin Dosage form Rats Rats Sprague-Dawley chemistry.chemical_compound Solubility X-Ray Diffraction Drug Discovery Microscopy Electron Scanning Animals Molecular Medicine Particle size Absorption (chemistry) Coaxial Dissolution |
| Zdroj: | Molecular Pharmaceutics. 8:807-813 |
| ISSN: | 1543-8392 1543-8384 |
| Popis: | Development of oral dosage forms containing poorly water-soluble drugs is a major challenge in the pharmaceutical industry. This paper describes the use of coaxial electrospray deposition as a promising formulation technology for oral delivery of poorly water-soluble drugs. The technology produced core-shell particles composed of griseofulvin and poly(methacrylic acid-co-methyl methacrylate) (Eudragit L-100), with a diameter of around 1 μm. The drug phase was in an amorphous state when the griseofulvin core was coated with the Eudragit L-100 shell. The in vitro dissolution and in vivo oral absorption studies revealed that the core-shell formulation significantly improved dissolution and absorption behaviors, presumably because of a reduction in particle size, improvement in dispersity, and amorphization. Results demonstrated that coaxial electrospray deposition possesses great potential as novel formulation technology for enhancing oral absorption of poorly water-soluble drugs. |
| Databáze: | OpenAIRE |
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