Timing of convalescent plasma administration and 28-day mortality in COVID-19 pneumonia

Autor:	Soledad E González, Lorena Regairaz, Martin R Salazar, Noelia S Ferrando, Verónica V González Martínez, Patricia M Carrera Ramos, Santiago A Pesci, Juan M Vidal, Nicolás Kreplak, Elisa Estenssoro
Rok vydání:	2022
Předmět:	Cohort Studies SARS-CoV-2 Immunization Passive COVID-19 Humans General Medicine COVID-19 Serotherapy General Biochemistry Genetics and Molecular Biology
Zdroj:	Journal of Investigative Medicine. 70:1258-1264
ISSN:	1708-8267 1081-5589
DOI:	10.1136/jim-2021-002158
Popis:	This is a multicenter cohort study including consecutive, hospitalized patients ≥18 years, with moderate to severe COVID-19, carried out to evaluate the relationship between the timing of convalescent plasma administration and 28-day mortality. Data were prospectively collected between May 14, 2020 and October 31, 2020. Patients were grouped according to the timing of administration of convalescent plasma as 7 days. The main outcome variable was 28-day mortality. Independent predictors of mortality were identified by logistic regression. Of 4719 patients receiving convalescent plasma, 3036 (64.3%) were in the general ward, 1171 (24.8%) in the intensive care unit (ICU), and 512 (10.8%) in the ICU on mechanical ventilation. Convalescent plasma was administered to 3113 (66%) patients within the first 3 days of hospital admission, to 1380 (29.2%) between 3 and 7 days, and to 226 after 7 days; 28-day mortality was, respectively, 18.1%, 30.4% and 38.9% (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6115e986f67fc95af4de64be144eee62 https://doi.org/10.1136/jim-2021-002158 Zobrazit plný text záznamu