The effect of indomethacin and enalapril on the cutaneous response to bradykinin
| Autor: | Lawrence G. McAlpine, Neil C. Thomson |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Indomethacin Prostaglandin Bradykinin Blood Pressure chemistry.chemical_compound Enalapril Internal medicine medicine Humans Pharmacology (medical) Skin Pharmacology integumentary system biology Drug Synergism Biological activity Angiotensin-converting enzyme Long-term potentiation Drug interaction Endocrinology chemistry Enzyme inhibitor biology.protein lipids (amino acids peptides and proteins) Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 27:870-872 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1989.tb03452.x |
| Popis: | The angiotensin converting enzyme inhibitors potentiate the wheal response to intradermal bradykinin. Both converting enzyme inhibitors and bradykinin stimulate prostaglandin synthesis and prostaglandins enhance the cutaneous response to bradykinin. We examined the possibility that the increased wheal response to intradermal bradykinin in the presence of enalapril was due to the effect of prostaglandins. Indomethacin did not inhibit the potentiation by enalapril of the wheal response to bradykinin. |
| Databáze: | OpenAIRE |
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