Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a Crucial Factor in Both Pathologies?
| Autor: | Carmen Sánchez-Torres, Yair Delgado-Namorado, Danira Toral-Rios, Elimar Torres-Ossorio, Victoria Campos-Peña, Fernando Becerril-Pérez, Diana Franco-Bocanegra, Karla Carvajal |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Clinical Biochemistry Disease Biology Bioinformatics Protein Aggregation Pathological Biochemistry 03 medical and health sciences 0302 clinical medicine Insulin resistance Alzheimer Disease Risk Factors Internal medicine Diabetes mellitus medicine Animals Humans Dementia Risk factor Molecular Biology General Environmental Science Inflammation Metabolic Syndrome Neurons Amyloid beta-Peptides Brain Cell Biology Lipid Metabolism medicine.disease Oxidative Stress Insulin receptor 030104 developmental biology Endocrinology Proteolysis biology.protein General Earth and Planetary Sciences Insulin Resistance Metabolic syndrome 030217 neurology & neurosurgery Dyslipidemia Signal Transduction |
| Zdroj: | Antioxidants & Redox Signaling. 26:542-560 |
| ISSN: | 1557-7716 1523-0864 |
| DOI: | 10.1089/ars.2016.6768 |
| Popis: | Recently, chronic degenerative diseases have become one of the main health problems worldwide. That is the case of Alzheimer's disease (AD) and metabolic syndrome (MetS), whose expression can be influenced by different risk factors. Recent Advances: In recent decades, it has been widely described that MetS increases the risk of cognitive impairment and dementia. MetS pathogenesis involves several vascular risk factors such as diabetes, dyslipidemia, hypertension, and insulin resistance (I/R).Reported evidence shows that vascular risk factors are associated with AD, particularly in the development of protein aggregation, inflammation, oxidative stress, neuronal dysfunction, and disturbances in signaling pathways, with insulin receptor signaling being a common alteration between MetS and AD.Insulin signaling has been involved in tau phosphorylation and amyloid β (Aβ) metabolism. However, it has also been demonstrated that Aβ oligomers can bind to insulin receptors, triggering their internalization, decreasing neuron responsiveness to insulin, and promoting insulin I/R. Thus, it could be argued that Aβ could be a convergent factor in the development of both pathologies. Antioxid. Redox Signal. 26, 542-560. |
| Databáze: | OpenAIRE |
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