An enhanced antibacterial nanoflowers AgPW@PDA@Nisin constructed from polyoxometalate and nisin
| Autor: | Yanfei Qi, Mingming Zhao, Xinming Zhang, Rongtian Sheng, Chenye Li, Yang Zhang, Hangjin Zou, Chuhan Zhang, Boyu Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
Scanning electron microscope Microbial Sensitivity Tests 010402 general chemistry Cell morphology 01 natural sciences Biochemistry Inorganic Chemistry chemistry.chemical_compound Minimum inhibitory concentration polycyclic compounds Zeta potential Nisin Minimum bactericidal concentration 010405 organic chemistry food and beverages Tungsten Compounds 0104 chemical sciences Anti-Bacterial Agents Nanostructures chemistry Transmission electron microscopy Microscopy Electron Scanning bacteria Antibacterial activity Nuclear chemistry |
| Zdroj: | Journal of inorganic biochemistry. 212 |
| ISSN: | 1873-3344 |
| Popis: | A new composite, AgPW@PDA@Nisin, with shell-core structure was successfully synthesized by a polydopamine (PDA) surfaced conjugated nisin (an antibacterial 34 amino acid polycyclic peptide) as shell and polyoxometalates (Ag3PW12O40 = AgPW) as core. The composite was characterized by the zeta potential, scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction analysis (XRD), fourier transform infrared (FT-IR). The AgPW@PDA@Nisin showed flower hierarchical structure and potential antibacterial activity against S. aureus ATCC29213. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of it were 4 and 32 μg/mL. AgPW@PDA@Nisin nanoflowers-induced bacterial death bears the characteristic of cell morphology, membrane integrity and permeability changing, nucleotide leakage. It indicated that the AgPW@PDA@Nisin interfere with the cell membrane, resulting in antibacterial activity against S. aureus. The cytotoxicity of the nanoflowers was low on HDF-a (human dermal fibroblasts) cells. A new class of hybrid inorganic-organic nanoflowers based on polyoxometalates and nisin with enhanced antibacterial properties can be developed for food preservation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect