Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage
| Autor: | Sang Hoon Jung, Hong Ryul Ahn, Kyung-A Kim, Chang Yong Lee, Cheol-Ho Pan, Holim Jang, Chu Won Nho, Hee Ju Lee, Chul Young Kim |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Retinal degeneration N-Methylaspartate Coumaric Acids Nerve Crush Apoptosis Asteraceae Pharmacology Biology medicine.disease_cause Neuroprotection Rats Sprague-Dawley Lipid peroxidation Mice chemistry.chemical_compound Caffeic Acids Retinal Diseases In vivo medicine Animals chemistry.chemical_classification Mice Inbred ICR Reactive oxygen species Plant Extracts Glaucoma Optic Nerve Succinates General Chemistry medicine.disease Rats Disease Models Animal Oxidative Stress Neuroprotective Agents medicine.anatomical_structure chemistry Biochemistry Retinal ganglion cell Lipid Peroxidation sense organs Chlorogenic Acid General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Journal of Agricultural and Food Chemistry. 62:1310-1323 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf4046232 |
| Popis: | We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-d-aspartate-induced damage to the rat retinas. In vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food. |
| Databáze: | OpenAIRE |
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