Predictors of imminent non-vertebral fracture in elderly women with osteoporosis, low bone mass, or a history of fracture, based on data from the population-based Canadian Multicentre Osteoporosis Study (CaMos)
| Autor: | Jerilynn C. Prior, Alexandra Papaioannou, David Goltzman, Claudie Berger, Stephanie M. Kaiser, Christopher S. Kovacs, Rich Barron, Amanda Silvia, Tassos Anastassiades, Erinda Shyta, Suzanne N Morin, K. Shawn Davison, George Ioannidis, Tanveer Towheed, Jonathan D. Adachi, Derek Weycker, Robert G. Josse, David A. Hanley, William D. Leslie, Stuart Jackson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Canada Osteoporosis Population 030209 endocrinology & metabolism Standard score Risk Assessment 03 medical and health sciences 0302 clinical medicine Bone Density Risk Factors Internal medicine Clinical Decision Rules medicine Back pain Humans Orthopedics and Sports Medicine education Femoral neck Aged Proportional Hazards Models Aged 80 and over education.field_of_study business.industry Femur Neck Hazard ratio medicine.disease medicine.anatomical_structure Orthopedic surgery Population study Accidental Falls Female 030101 anatomy & morphology medicine.symptom business Osteoporotic Fractures |
| Zdroj: | Archives of osteoporosis. 14(1) |
| ISSN: | 1862-3514 |
| Popis: | Using data from the Canadian Multicentre Osteoporosis Study, several risk factors predictive of imminent (2-year) risk of low-trauma non-vertebral fracture among high-risk women were identified, including history of falls, history of low-trauma fracture, poorer physical function, and lower T score. Careful consideration should be given to targeting this population for therapy. Fracture risk assessment has focused on a long-term horizon and populations with a broad risk range. For elderly women with osteoporosis or low bone mass, or a history of fragility fractures (“high-risk women”), risk prediction over a shorter horizon may have greater clinical relevance. A repeated-observations design and data from the Canadian Multicentre Osteoporosis Study were employed. Study population comprised women aged ≥ 65 years with T score (total hip, femoral neck, spine) ≤ − 1.0 or prior fracture. Hazard ratios (HR) for predictors of low-trauma non-vertebral fracture during 2-year follow-up were estimated using multivariable shared frailty model. The study population included 3228 women who contributed 5004 observations; 4.8% experienced low-trauma non-vertebral fracture during the 2-year follow-up. In bivariate analyses, important risk factors included age, back pain, history of falls, history of low-trauma fracture, physical function, health status, and total hip T score. In multivariable analyses, only four independent predictors were identified: falls in past 12 months (≥ 2 falls: HR = 1.9; 1 fall: HR = 1.5), low-trauma fracture in past 12 months (≥ 1 fracture: HR = 1.7), SF-36 physical component summary score (≤ 42.0: HR = 1.6), and total hip T score (≤ − 3.5: HR = 3.7; > − 3.5 to ≤ − 2.5: HR = 2.5; > − 2.5 to ≤ − 1: HR = 1.3). Imminent risk of low-trauma non-vertebral fracture is elevated among high-risk women with a history of falls or low-trauma fracture, poorer physical function, and lower T score. Careful consideration should be given to identifying and targeting this population for therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink