Syntheses, structural characterization, DNA-cleavage and antioxidant features of the new tetra-substituted organo-soluble non-peripherally CoII, CuII, ZnII and MgII phthalocyanines

Autor:	Halit Kantekin, Gülpınar Sarkı, Yasemin Ünver, Burak Barut, Beytullah Ertem, Halise Yalazan, Arzu Özel
Rok vydání:	2019
Předmět:	Antioxidant biology Chemistry Stereochemistry DPPH medicine.medical_treatment 010402 general chemistry 010403 inorganic & nuclear chemistry biology.organism_classification 01 natural sciences PBR322 0104 chemical sciences chemistry.chemical_compound Plasmid Plasmid dna Dna cleavage Materials Chemistry medicine Tetra Physical and Theoretical Chemistry
Zdroj:	Journal of Coordination Chemistry. 72:2409-2421
ISSN:	1029-0389 0095-8972
Popis:	This paper encompasses the synthesis, structural characterization, and evaluation of supercoiled pBR322 plasmid DNA-cleavage and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging properties of newly synthesized tetra-substituted CoII (5), CuII (6), ZnII (7) and MgII (8) phthalocyanines bearing 4-methyl-N-(4-morpholinophenyl)benzenesulfonamide units at non-peripheral sites of phthalocyanine skeleton. The structural characterization of these new metallated phthalocyanines were performed via UV-vis, elemental analysis, FT-IR (ATR sampling accessory), 1H-NMR and 13C-NMR spectroscopic techniques (for 7 and 8) and MALDI-TOF mass spectral data. The new compounds (5–8) exhibited good solubility in common organic solvents, and as well as no sort of aggregation was perceived at studied concentrations and solvents. Compound 7 indicated oxidative photocleavage activities in the presence of H2O2, indicating the conversion of supercoiled pBR322 plasmid DNA to nicked circular form (19.90%) and linear form (4.40%). Compound 5 displayed the highest radical scavenging activities among the tested compounds. The DPPH-radical scavenging percentages of 5 ranged from 85.35 ± 2.45% (12.5 µM) to 95.38 ± 1.44% (100 µM). These compounds are favorable for further research, owing to a broad range of biological and pharmaceutical activities of morpholine scaffold.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610eec1d631d66da43db3f071e6fa1d5 https://doi.org/10.1080/00958972.2019.1648795 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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