Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines

Autor:	J. C. Craig, P. R. Findell, Richard I. Weiner, S. M. Torkelson
Rok vydání:	1989
Předmět:	Chemistry Stereochemistry Dopaminergic Dopamine Agents Molecular Conformation In Vitro Techniques Dopamine agonist Structure-Activity Relationship Dopamine Drug Discovery medicine Radioligand Quinolines Molecular Medicine Animals Cattle Ergolines medicine.drug
Zdroj:	Journal of medicinal chemistry. 32(5)
ISSN:	0022-2623
Popis:	A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610bf5b72c476b144f9786f281a46ec9 https://pubmed.ncbi.nlm.nih.gov/2565402 Zobrazit plný text záznamu