Effect of Lithium Preparations on Cerebral Electrophysiological Activity in Rats
| Autor: | E E Rachkovskii, T. V. Popova, Robinson Mv, T. N. Povet’eva, A. Yu. Letyagin, A. A. Kotlyarova, A. V. Shurlygina, L. N. Rachkovskaya, Vladimir I. Konenkov, O. G. Afanas’eva, Maxim Aleksandrovich Korolev, Yu. V. Nesterova, Nadezhda Shilova, N. I. Suslov, P. V. Kul’pin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Lithium (medication) Photic Stimulation Silicones Salt (chemistry) Lithium Pharmacology 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lithium Carbonate Aluminum Oxide medicine Animals Citrates Cerebral Cortex chemistry.chemical_classification Chemistry Lithium carbonate Brain General Medicine Reference drug Electrophysiological Phenomena Rats Electrophysiology Visual cortex medicine.anatomical_structure Cerebral cortex 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:470-473 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The study examined the effects of a novel neurotropic medication based on a lithium complex composed of lithium citrate, polymethylsiloxane, and aluminum oxide on electrophysiological parameters of the rat brain. In contrast to lithium carbonate (the reference drug), the novel preparation resulted in a wave-like dynamics of electrical activity in the visual cortex. Rhythmic photic stimulation of the rats treated with lithium carbonate resulted in appearance of the signs attesting to up-regulation of excitability of cerebral cortex in all examined ranges. In contrast, the complex lithium preparation diminished the delta power spectrum, which was the only affected frequency band. It is hypothesized that the complex lithium medication induces milder activation of the cerebral cortex in comparison with lithium carbonate. The novel medication composed of lithium citrate, aluminum oxide, and polymethylsiloxane, is characterized by greater efficacy and safety than the preparation based on inorganic lithium salt (lithium carbonate). |
| Databáze: | OpenAIRE |
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