In vitro metabolism of citalopram by monoamine oxidase B in human blood
| Autor: | Anne-Catherine Aubert, Pierre Baumann, M. Amey, Markus Kosel |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Monoamine oxidase
Pharmacology Citalopram In Vitro Techniques Reference Values medicine Humans Pharmacology (medical) Platelet Monoamine Oxidase Biological Psychiatry chemistry.chemical_classification Chemistry Platelet Count Metabolism Antidepressive Agents Psychiatry and Mental health Enzyme Neurology Antidepressant Neurology (clinical) Monoamine oxidase B Drug metabolism medicine.drug |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 11(1) |
| ISSN: | 0924-977X |
| Popis: | The metabolism of the antidepressant citalopram (CIT) by monoamine oxidase B (MAO-B) was studied in vitro. In incubations with blood of nine healthy volunteers R-(P=0.015) and S-(P=0.0034) CIT propionic acid (CITPROP) production was correlated with the number of platelets. S-CITPROP production was 5.6 times higher than R-CITPROP production and in incubations containing the MAO-B inhibitor deprenyl, racemic CITPROP production was diminished to 9.1%. To our knowledge, this is the first time that MAO-B activity in blood is shown with an antidepressant as substrate. As MAO is strongly expressed in human brain, this observation suggests that this enzymatic system may be implicated in drug metabolism in the CNS. |
| Databáze: | OpenAIRE |
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