Impact of reducing day 1 dexamethasone dose in anthracycline-containing regimens on acute gastrointestinal symptoms associated with breast cancer treatment
| Autor: | Yoh Takekuma, Takashi Takeshita, Mitsuru Sugawara, Yoshitaka Saito |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Risk medicine.medical_specialty Time Factors Anthracycline Nausea Vomiting Science Breast Neoplasms Anorexia Gastroenterology Article Dexamethasone Breast cancer Medical research Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Anthracyclines Cancer Aged Retrospective Studies Multidisciplinary Antibiotics Antineoplastic Drug Tapering business.industry Incidence (epidemiology) Incidence Patient Acuity Middle Aged medicine.disease Oncology Medicine Female Dexamethasone Dose medicine.symptom business medicine.drug |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The potential of steroid sparing from day 2 onward is reported in anthracycline-containing regimens for breast cancer treatment. We evaluated whether the reduction of dexamethasone (DEX) dose from 9.9 to 6.6 mg on day 1 is possible in anthracycline-containing treatments. Patients receiving anthracycline-containing regimens were divided into control (9.9 mg DEX on day 1) and reduced (6.6 mg DEX on day 1) groups, and retrospectively evaluated. The complete response (CR) rate and the incidence and severity of nausea, vomiting, anorexia, and fatigue were evaluated. The CR rate in the acute phase (day 1) was 63.1% and 38.1% in the control and reduced groups, respectively, with significant difference (P = 0.01) between the groups. However, no difference was found in the delayed phase (days 2–7). The incidence of anorexia and vomiting during treatment was not statistically different. Severity of nausea tended to, but not statistically, worsen while anorexia significantly worsened in the reduced group. Multivariate analysis suggested that patients |
| Databáze: | OpenAIRE |
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