A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons
| Autor: | Wolf Huetteroth, Joachim Schachtner, Kevin C. Daly, Erich M. Staudacher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Olfactory system Manduca sexta L Identified glomerul Population Neurophysiology Moth Sensory system Olfaction Biology Brain mapping Article 03 medical and health sciences 0302 clinical medicine Species Specificity ddc:570 Manduca Image Processing Computer-Assisted medicine Animals Projection (set theory) education Spike time resolution Fluorescent Dyes 030304 developmental biology Neurons Brain Mapping 0303 health sciences education.field_of_study Staining and Labeling General Neuroscience Brain Signal Processing Computer-Assisted Intracellular recording and staining Olfactory Pathways Ganglia Invertebrate 3-Dimensional reconstruction Electrophysiology Smell medicine.anatomical_structure Data Interpretation Statistical Antennal lobe Neuroscience Ensemble analysis 030217 neurology & neurosurgery |
| Popis: | A central problem facing studies of neural encoding in sensory systems is how to accurately quantify the extent of spatial and temporal responses. In this study, we take advantage of the relatively simple and stereotypic neural architecture found in invertebrates. We combine standard electrophysiological techniques, recently developed population analysis techniques, and novel anatomical methods to form an innovative 4-dimensional view of odor output representations in the antennal lobe of the moth Manduca sexta. This novel approach allows quantification of olfactory responses of characterized neurons with spike time resolution. Additionally, arbitrary integration windows can be used for comparisons with other methods such as imaging. By assigning statistical significance to changes in neuronal firing, this method can visualize activity across the entire antennal lobe. The resulting 4-dimensional representation of antennal lobe output complements imaging and multi-unit experiments yet provides a more comprehensive and accurate view of glomerular activation patterns in spike time resolution. |
| Databáze: | OpenAIRE |
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