Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia
| Autor: | Mihailo Matic, Natasa Milic, Ljiljana Soskic, Ivana I. Vranic, Tijana Simic, Jovan Perunicic |
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| Rok vydání: | 2005 |
| Předmět: |
Tachycardia
Adult Male medicine.medical_specialty Adenosine Cardiotonic Agents Heart disease Clinical Biochemistry Myocardial Ischemia 6-Ketoprostaglandin F1 alpha Thromboxane A2 Bolus (medicine) Internal medicine medicine Tachycardia Supraventricular Humans Sinus rhythm Cardioprotective Agent Tachycardia Paroxysmal Cardioprotection business.industry Cell Biology Middle Aged medicine.disease Thromboxane B2 Verapamil Cardiology Prostaglandins Female medicine.symptom business medicine.drug |
| Zdroj: | Prostaglandins, leukotrienes, and essential fatty acids. 74(6) |
| ISSN: | 0952-3278 |
| Popis: | PSVT attack of >20min and frequency >160 is well-recognized model of myocardial dysfunction. We measured 6-keto-PGF1alpha and TXB(2) before and after adenosine administration to assess its cardioprotective potential. A total of 64 patients were randomly assigned as having acute episode of PSVT to adenosine or verapamil group. A bolus of 6mg of adenosine up to the maximum dose of 12 or 5mg of verapamil up to the maximum dose of 10mg were given, until the sinus rhythm was restored. The levels of PGI(2), TXA(2) and TAS were measured in three different time intervals. In adenosine group all parameters were normalized after 20min of conversion to sinus rhythm. The ratio of PGI(2)/TXA(2) increased after 5min of conversion to SR (P |
| Databáze: | OpenAIRE |
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