Parallel inhibition of neutrophil arachidonic acid metabolism and lysosomal enzyme secretion by nordihydroguaiaretic acid
| Autor: | R.W. Walenga, H.J. Showell, Elmer L. Becker, M.B. Feinstein |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Cytochalasin B
Neutrophils CYP1B1 Catechols Arachidonic Acids General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Lipoxygenase medicine Animals Masoprocol Secretion Cytochalasin General Pharmacology Toxicology and Pharmaceutics biology Dose-Response Relationship Drug General Medicine Nordihydroguaiaretic acid chemistry Biochemistry biology.protein Arachidonic acid Muramidase Rabbits medicine.drug |
| Zdroj: | Life sciences. 27(12) |
| ISSN: | 0024-3205 |
| Popis: | Arachidonic acid at concentrations from 0.2 to 2.0 × 10−6M induces the secretion of lysosomal enzymes from cytochalasin B-treated rabbit neutrophils. These concentrations of arachidonic acid are metabolized primarily to hydroxyeicosatetraenic acids rather than to cyclooxygenase products. A good correlation is observed between the extent of arachidonic acid metabolism and the secretion of lysosomal enzymes. Nordihydroguaiaretic acid (1−10μM) inhibits both lysosomal enzyme secretion and the production of lipoxygenase products by neutrophils. |
| Databáze: | OpenAIRE |
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