Corticosteroid modulation and testosterone changes during alcohol intoxication affects voluntary alcohol drinking

Autor: Tiina J. Etelälahti, C.J.P. Eriksson, S.J. Apter
Přispěvatelé: Clinicum, University of Helsinki, Department of Public Health, Biosciences
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
STRESS
Clinical Biochemistry
NONPREFERRING RATS
Alcohol
Toxicology
Biochemistry
Behavioral Neuroscience
chemistry.chemical_compound
Basal (phylogenetics)
0302 clinical medicine
Alcohol intoxication
Corticosterone
Testosterone
CHRONIC ETHANOL TREATMENT
BRAIN
CORTICOTROPIN-RELEASING-FACTOR
317 Pharmacy
Corticosteroid
HORMONES
Psychology
medicine.medical_specialty
Alcohol Drinking
medicine.drug_class
HPA and HPG axes
03 medical and health sciences
Internal medicine
medicine
Animals
Rats
Wistar
Biological Psychiatry
Pharmacology
BETA-ENDORPHIN
3112 Neurosciences
CONSUMPTION
Testosterone (patch)
medicine.disease
Rats
030104 developmental biology
Endocrinology
chemistry
NEUROADAPTATION
High and low alcohol drinking rats
PITUITARY-ADRENAL AXIS
beta-Endorphin
Alcoholic Intoxication
Voluntary alcohol consumption
Biomarkers
030217 neurology & neurosurgery
Hormone
Zdroj: Pharmacology Biochemistry and Behavior. 157:9-15
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2017.04.011
Popis: A number of studies have shown that stress and an activated hypothalamic-pituitary-adrenal (HPA) axis are associated with increased voluntary alcohol drinking. Recently, associations have been found between activated HPA and hypothalamic-pituitary-gonadal (HPG) axes in alcohol-preferring AA and non-preferring ANA, F2 (crossbred second generation from original AA and ANA), and Wistar rats. The aim of the present study has been to determine the role of corticosterone and alcohol-related testosterone-effects in subsequent alcohol drinking in AA, ANA, F2 and Wistar rats. The present study comprises of four substudies presenting new analyses of existing data, by which correlations between basal corticosterone levels, changes in testosterone levels during alcohol intoxications and subsequent voluntary alcohol consumption are investigated. The results displayed positive correlations between basal corticosterone levels and subsequent alcohol-mediated testosterone elevations, which was positively associated with voluntary alcohol consumption. The results also showed a negative correlation between basal corticosterone levels and alcohol-mediated testosterone decreases, which was negatively associated with alcohol consumption. In conclusion, the present study displays novel results, according to which the HPA axis, one hand, relates to testosterone elevation (potentially causing and/or strengthening reinforcement) during alcohol intoxication, which in turn may relate to higher voluntary alcohol consumption (AA rats). Vice versa, the HPA axis may also relate to alcohol-mediated testosterone decrease (causing testosterone reduction and disinforcement) and low-alcohol drinking (ANA, F2 and Wistar rats). In addition, the present results showed that alcohol-mediated testosterone changes may also, independently of the HPA axis, correlate with voluntary alcohol drinking, which indicate the impact of genetic factors. Thus, the role of the HPA-axis may be more related to situational stress than to intrinsic factors. In further studies, it should be investigated, whether the present results also apply to stress and human alcohol drinking.
Databáze: OpenAIRE
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