Long Lasting Supersensitivity to 5-HT Mediated Behaviour Following Monoamine Depletion in the Rat Brain
| Autor: | Lucy Rényi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Biogenic Amines Serotonin medicine.medical_specialty Methoxydimethyltryptamines Reserpine Central nervous system Toxicology chemistry.chemical_compound Internal medicine Biogenic amine medicine Fenclonine Animals Ejaculation Neurotransmitter 5-HT receptor Brain Chemistry Pharmacology chemistry.chemical_classification Behavior Animal Chemistry Drug Synergism Rats Inbred Strains Rats Endocrinology medicine.anatomical_structure Monoamine neurotransmitter medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 59:298-302 |
| ISSN: | 0001-6683 |
| Popis: | The effects of the depletion of 5-hydroxytryptamine (5-HT) in the rat brain upon the 5-HT behavioural syndrome (ejaculatory response, abduction of hind-limbs, forepaw treading, and Straub tail) induced by 5-methoxy-N,N-dimethyltryptamine (1 mg/kg intraperitoneally) were investigated. The 5-HT depletion was produced by p-chlorophenylalanine (PCPA 2 X 200 mg/kg intraperitoneally) or by reserpine (5 mg/kg subcutaneously). It resulted in rapidly developing and long-lasting supersensitivity of the behavioural responses which were enhanced between 2 and 14 days after the PCPA injections and between 1 and 42 days after a single dose of reserpine. The depletion of catecholamines by alpha-methyltyrosine (250 + 125 mg/kg intraperitoneally) had no effect. These results underline the usefulness of the 5-HT mediated behavioural models for studies of changes in 5-HT receptor activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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