Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review
| Autor: | Shoujin Sun, Ylva Delmar, Rodney Anthony Stewart, Daniel Martinez-Marquez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Materials science porous implants porosity 0206 medical engineering chemistry.chemical_element elastic modulus Nanotechnology 02 engineering and technology Review mechanical properties lcsh:Technology Quality by Design unit cell General Materials Science pore size titanium Bone regeneration Porosity lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 lcsh:T bone implants Titanium alloy 021001 nanoscience & nanotechnology compressive strength 020601 biomedical engineering Compressive strength metamaterials chemistry lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering 0210 nano-technology Engineering design process lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 additive manufacturing Titanium |
| Zdroj: | Materials Materials, Vol 13, Iss 4794, p 4794 (2020) |
| ISSN: | 1996-1944 |
| Popis: | Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone regeneration. However, increased porosity results in decreased material strength. The porosity and pore sizes that are ideal for porous implants are still controversial in the literature, complicating the justification of a design decision. Recently, metallic porous biomaterials have been proposed for load-bearing applications beyond surface coatings. This recent science lacks standards, but the Quality by Design (QbD) system can assist the design process in a systematic way. This study used the QbD system to explore the Quality Target Product Profile and Ideal Quality Attributes of additively manufactured titanium porous scaffolds for bone regeneration with a biomimetic approach. For this purpose, a total of 807 experimental results extracted from 50 different studies were benchmarked against proposed target values based on bone properties, governmental regulations, and scientific research relevant to bone implants. The scaffold properties such as unit cell geometry, pore size, porosity, compressive strength, and fatigue strength were studied. The results of this study may help future research to effectively direct the design process under the QbD system. |
| Databáze: | OpenAIRE |
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