Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol
| Autor: | Fuat Gundogdu, Sebahattin Ateşal, Şakir Arslan, Mahmut Acikel, Mustafa Kemal Erol, Engin Bozkurt, Hüseyin Şenocak |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Metoprolol Succinate Adrenergic beta-Antagonists Carbazoles Severity of Illness Index Ventricular Function Left Propanolamines Internal medicine Mitral valve Natriuretic Peptide Brain medicine Natriuretic peptide Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Carvedilol Aged Metoprolol Heart Failure Ejection fraction Cardiac cycle business.industry Middle Aged medicine.disease Echocardiography Doppler Peptide Fragments Treatment Outcome medicine.anatomical_structure Heart failure Cardiology Atrial Function Left Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The International Journal of Cardiovascular Imaging. 23:549-555 |
| ISSN: | 1573-0743 1569-5794 |
| Popis: | We aimed to compare the effects of carvedilol and metoprolol succinate on left atrial (LA) function in patients with chronic heart failure. Thirty three patients (6 females, 27 males) who had not received β blocker treatment previously and whose left ventricular ejection fraction was below 40% were included in this study. LA volumes were measured echocardiographically just before the time of mitral valve opening (V max), onset of atrial systole (p-wave at the electrocardiography = V p) and mitral valve closure (V min) according to the biplane area length method at baseline and in the 3rd month after the administration of β blockers. NT-proBNP level was measured at the beginning and in the third month of β blocker treatment. The first group was given carvedilol 6.25 mg/day, the second group was given 12.5 mg/day metoprolol succinate and it was increased to the tolerable maximal dose. LA diameter and LA V max, V p, V min decreased significantly both in carvedilol group and metoprolol group after β blocker theraphy (P |
| Databáze: | OpenAIRE |
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