Chronic Instrumentation With Model Microstimulators in an Animal Model of the Lower Urinary Tract
| Autor: | Robert D. Wurster, John S. Wheeler, James S. Walter, Allison McDonnell, Mary P. FitzGerald |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Urinary system media_common.quotation_subject Urinary Bladder Urology Electric Stimulation Therapy Urination Animal model Animals Medicine Urinary Bladder Neurogenic Spinal cord injury Spinal Cord Injuries media_common Hypogastric Plexus business.industry Urinary retention Urination disorder medicine.disease Electrodes Implanted Disease Models Animal Urodynamics Urinary Tract Physiology Cats Feasibility Studies Female Neurology (clinical) medicine.symptom business Follow-Up Studies |
| Zdroj: | The Journal of Spinal Cord Medicine. 28:114-120 |
| ISSN: | 2045-7723 1079-0268 |
| DOI: | 10.1080/10790268.2005.11753808 |
| Popis: | Microstimulators are a new type of neuroprosthetic device that should be considered for applications such as micturition control after spinal cord injury (SCI). These devices are small (less than 25 mm by 5 mm) and the electrodes are located on the ends of the stimulator. The aim of the current study was to develop methods for chronic implantation of model microstimulators (M-Micro) on the bladder wall and pelvic plexus of female cats. A postmortem evaluation of the effects of 3 months of implantation is reported.Techniques to produce the M-Micro are described. Four of these devices were implanted in 4 female cats and maintained after the initial instrumentation surgery and a second survival surgery for SCI (at T10). Using a single suture tied around the M-Micro, these devices were secured to the bladder wall or the fat pads adjacent to the pelvic plexus. Additional instrumentation was implanted, including 2 catheters in the bladder, 1 abdominal balloon, and electromyography electrodes in the urethral and anal sphincters. Postmortem observations of the location of the M-Micro on the bladder wall were conducted after fixation.The animals' conditions were good. One animal was sacrificed early because of a skin infection. A single suture was sufficient to anchor the M-Micro. However, during the surgical implantation the pelvic plexus M-Micro ended up close to the bladder neck. Extensive fibrous connective tissue formed around the M-Micro and implanted catheters on the bladder wall. This appeared to result, in part, from multiple devices implanted on or near the bladder wall.These pilot studies showed that the M-Micro could be easily constructed and secured to the bladder wall or fat pads close to the pelvic plexus. There was a concern that the pelvic plexus location for the M-Micro ended near the bladder neck during the surgical implantation; however, these devices did not appear to migrate over this short, 3-month implantation period. The extensive connective tissue responses of the bladder wall to the tubes, wires, and M-Micro was a major concern. The M-Micro appears to be a good device to assess the potential of commercial microstimulators for use in micturition control. |
| Databáze: | OpenAIRE |
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