Staphylococcal Vaccine Antigens related to biofilm formation
| Autor: | Sina Valinejad, Bahman Mirzaei, Ryhaneh Babaei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus medicine.medical_treatment 030231 tropical medicine Immunology Biology medicine.disease_cause Staphylococcal infections Microbiology 03 medical and health sciences 0302 clinical medicine Staphylococcus epidermidis medicine Immunology and Allergy Humans 030212 general & internal medicine Pharmacology Immunogenicity Biofilm Staphylococcal Vaccines Immunotherapy biochemical phenomena metabolism and nutrition Staphylococcal Infections Vaccine efficacy medicine.disease biology.organism_classification Anti-Bacterial Agents Biofilms Commentary Bacteria |
| Zdroj: | Hum Vaccin Immunother |
| Popis: | The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy. |
| Databáze: | OpenAIRE |
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