Xath2, a bHLH gene expressed during a late transition stage of neurogenesis in the forebrain of Xenopus embryos
| Autor: | Eric Bellefroid, Kenneth Ryan, Vincent Taelman, Karin Opdecamp, Bernard Avalosse |
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| Rok vydání: | 2001 |
| Předmět: |
Embryology
DNA Complementary Embryo Nonmammalian Time Factors animal structures Xenopus Molecular Sequence Data Nerve Tissue Proteins Proneural genes Xenopus Proteins Biology Mice Prosencephalon Tubulin Basic Helix-Loop-Helix Transcription Factors Animals Tissue Distribution Amino Acid Sequence Cloning Molecular Gene In Situ Hybridization Gene Library Neurons NeuroD Sequence Homology Amino Acid Neurogenesis biology.organism_classification Molecular biology Neuroepithelial cell Bromodeoxyuridine nervous system Neurula embryonic structures Forebrain Transcription Factors Developmental Biology |
| Zdroj: | Mechanisms of Development. 101:199-202 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(00)00546-3 |
| Popis: | We have identified a Xenopus bHLH gene, Xath2, which is the homologue of the murine MATH-2/NEX-1 gene, using a functional expression screening approach. Overexpression of this gene in neurula embryos induces the expression of the N-tubulin neuronal marker but does not stimulate the expression of the X-ngnr-1 and NeuroD proneural genes. Expression of Xath2 begins in stage 32 embryos and is restricted to the dorsal telencephalon. Within the neuroepithelium of the dorsal telencephalon, Xath2 expression is detected in postmitotic cells located more laterally than those expressing several other related bHLH neuronal regulators. |
| Databáze: | OpenAIRE |
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