Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes

Autor: Joel H. Kramer, Katherine L. Possin, Michael D. Geschwind, Duan Xu, Alexandra C. Apple, Bruce L. Miller, Sharon J. Sha, Hosung Kim, Christopher P. Hess, Tacie Moskowitz, Steven Finkbeiner, Erica T. Johnson
Rok vydání: 2016
Předmět:
Male
Caudate
Caudate nucleus
Hippocampus
Dorsolateral
Hippocampal formation
Neuropsychological Tests
Imaging
Behavioral Neuroscience
0302 clinical medicine
Psychology
Contrast (vision)
media_common
Spatial Memory
05 social sciences
Experimental Psychology
Organ Size
Middle Aged
Magnetic Resonance Imaging
Navigation
medicine.anatomical_structure
Huntington Disease
Memory
Short-Term
Social Perception
Visual Perception
Biomedical Imaging
Cognitive Sciences
Female
Algorithms
Adult
Cognitive Neuroscience
media_common.quotation_subject
Experimental and Cognitive Psychology
050105 experimental psychology
Article
03 medical and health sciences
Imaging
Three-Dimensional
Huntington's disease
Memory
medicine
Humans
0501 psychology and cognitive sciences
Analysis of Variance
Working memory
Neurosciences
medicine.disease
Self Concept
Dorsolateral prefrontal cortex
Short-Term
Three-Dimensional
Caudate Nucleus
Neuroscience
Visuospatial
030217 neurology & neurosurgery
Zdroj: Neuropsychologia. 101
ISSN: 1873-3514
Popis: Our brains represent spatial information in egocentric (self-based) or allocentric (landmark-based) coordinates. Rodent studies have demonstrated a critical role for the caudate in egocentric navigation and the hippocampus in allocentric navigation. We administered tests of egocentric and allocentric working memory to individuals with premotor Huntington’s disease (pmHD), which is associated with early caudate nucleus atrophy, and controls. Each test had 80 trials during which subjects were asked to remember 2 locations over 1-sec delays. The only difference between these otherwise identical tests was that locations could only be coded in self-based or landmark-based coordinates. We applied a multiatlas-based segmentation algorithm and computed point-wise Jacobian determinants to measure regional variations in caudate and hippocampal volumes from 3 T MRI. As predicted, the pmHD patients were significantly more impaired on egocentric working memory. Only egocentric accuracy correlated with caudate volumes, specifically the dorsolateral caudate head, right more than left, a region that receives dense efferents from dorsolateral prefrontal cortex. In contrast, only allocentric accuracy correlated with hippocampal volumes, specifically intermediate and posterior regions that connect strongly with parahippocampal and posterior parietal cortices. These results indicate that the distinction between egocentric and allocentric navigation applies to working memory. The dorsolateral caudate is important for egocentric working memory, which can explain the disproportionate impairment in pmHD. Allocentric working memory, in contrast, relies on the hippocampus and is relatively spared in pmHD.
Databáze: OpenAIRE
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