Relationship between plasma levels of soluble CD40L and insulin sensitivity and insulin secretion status in non-diabetic dyslipidemic patients
| Autor: | Paloma Muñoz-Pacheco, María Luisa González-Rubio, Arturo Fernández-Cruz, Arántzazu Alvarez-Arcaya, Alfonso L. Calle-Pascual, Leonardo Reinares, Claudia Filozof, Antonio Rueda, Dulcenombre Gómez-Garre |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism medicine.medical_treatment CD40 Ligand Blood Pressure chemistry.chemical_compound Endocrinology Insulin resistance Diabetes mellitus Internal medicine Insulin Secretion Internal Medicine medicine Body Size Humans Insulin Receptor Dyslipidemias Triglyceride business.industry Body Weight General Medicine Middle Aged Flow Cytometry medicine.disease Blood pressure chemistry Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Resistance business Homeostasis |
| Zdroj: | Diabetes Research and Clinical Practice. 79:48-55 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2007.07.002 |
| Popis: | We have measured circulating plasma sCD40L as well as the platelet-surface of CD40L and its receptor in a sample of non-diabetic dyslipidemic patients and then evaluated its relationship with the insulin resistance (IR) and insulin secretion (IS) status.Anthropometric measurements, fasting glucose, insulin, lipids, and IR and IS [estimated by the homeostasis model assessment (HOMA)] were assessed in 86 dyslipidemic subjects. Circulating sCD40L were determined by ELISA. By flow cytometry, CD40L, CD40 and P-selectin were evaluated in the platelet-surface.Non-diabetic dyslipidemic IR patients (HOMA-IRor=3.8) showed higher plasma sCD40L concentrations and a more unfavorable cardiovascular risk profile (higher BMI, waist, fasting insulin and mean triglyceride levels) than dyslipidemic patients with low IS (HOMA beta-cell98). In a multivariable model, only measures of insulin sensitivity and higher waist remained significantly associated with increased plasma levels of sCD40L. Surface expression of CD40L on platelets decreased significantly and CD40 increased in IR patients, compared with patients with low IS.IR dyslipidemic patients show increased plasma sCD40L and decreased platelet-membrane CD40L expression compared to dyslipidemic patients with low IS. |
| Databáze: | OpenAIRE |
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