Whole-brain functional mapping with isotropic MR imaging
| Autor: | Daniel R. Weinberger, Jeff H. Duyn, Attanagoda K. S. Santha, Alan C. McLaughlin, Joseph A. Frank, James J. Pekar, Venkata S. Mattay |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cerebellum computer.software_genre symbols.namesake Voxel Motor system medicine Humans Radiology Nuclear Medicine and imaging Brain Mapping medicine.diagnostic_test Echo-Planar Imaging business.industry Isotropy Magnetic resonance imaging Magnetic Resonance Imaging Mr imaging Functional mapping Bonferroni correction medicine.anatomical_structure symbols Female business Nuclear medicine computer |
| Zdroj: | Radiology. 201:399-404 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.201.2.8888231 |
| Popis: | To assess the reliability and sensitivity of gradient-echo, isotropic multisection echo-planar magnetic resonance (MR) imaging for within-subject whole-brain mapping.Eight right-handed healthy volunteers underwent gradient-echo, echo-planar MR imaging while they performed a motor task on three occasions over 2-3 months. Ninety-six whole-brain volumes were acquired in 8 minutes 48 seconds. A rigorous statistical threshold for determining activation was set at P.05 and was Bonferroni corrected for approximately 15,000 cortical voxels.In all subjects, reproducible activation was demonstrated in multiple cortical areas and in the cerebellum specific to the motor system. Of the activated voxels, 75%-78% were confined to the motor areas during all sessions. No statistically significant difference was found in the proportion of activated voxels in any motor region (relative to the total number of activated voxels in the whole brain) across the three sessions. The centers of mass of the activated areas were within 2.5 resolution elements of the image across the three sessions.Isotropic multisection echo-planar MR imaging, has the potential for noninvasive, reliable within-subject mapping of whole-brain functional anatomy. |
| Databáze: | OpenAIRE |
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