| Autor: |
Manuel Hidalgo, Laureano Simon, Wolfgang Richter, Muhammad Abbas, Sofia Perea, Pedro P. López-Casas, María dM. Vivanco, So Young Lee, Klaus Pfizenmaier, Roland E. Kontermann, Stephan A. Eisler, Oliver Seifert, Laura Murias, Bruno Bockorny, Saioa Domínguez-Hormaetxe, Cristina Ferrer, Myriam Fabre |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22477374.v1 |
| Popis: |
S1-S7 all supplementary figures with their legends: S1:Figure S1. OMTX705 binding and internalization in HT1080-WT, -FAP and CAFs S2:Weight change of mice bearing Panc 007, Lung 024 and Breast 014 tumors. S3: OMTX705 Activity in the Immunodeficient Patient Derived Xenografts (PDX) Models of Ovarian Cancer. S4: FAP immunostaining in frozen tumor samples from humanized mice bearing CTG-0860 NSCLC PDX tumor. S5: Separate fluorescent staining of human IgG, Rab7 and nuclei in OMTX705 and OMTX005 treated HT1080-FAP cells (complements the merged image of figure 4C) S6: Immunohistochemical analysis of payload, OMTX005 and OMTX705 distribution in tumors from Panc 007 model. S7: Schematic summary of findings and proposed mechanism of action of OMTX705. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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