Association of Irs1 GLY971ARG Gene Polymorphism With Insulin Resistance in Iranian Newly Diagnosed Diabetic Adults
| Autor: | A Farahi, H Shakeri, R Mohammadi, M Kaffash Bajestani, Amirhosein Khoshi, Z Hosseini, M S Javadzadeh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Diabetes mellitus Internal medicine medicine General Endocrinology biology Endocrine and Autonomic Systems business.industry Insulin medicine.disease IRS1 Insulin receptor 030220 oncology & carcinogenesis biology.protein Gene polymorphism business Homeostasis |
| Zdroj: | Acta Endocrinologica (Bucharest). 15:317-322 |
| ISSN: | 1843-066X 1841-0987 |
| DOI: | 10.4183/aeb.2019.317 |
| Popis: | Context Insulin receptor substrate-1 (IRS-1) has an important role in insulin signaling and the common Gly971Arg polymorphism is related to type 2 diabetes (T2D). IRS-1 Gly971Arg polymorphism can modify tyrosine phosphorylation at a specific site of IRS-1 and may have a critical role in the development of insulin resistance (IR). Objective The purpose of this study was to investigate the association between this polymorphism and IR in Iranian patients with newly-diagnosed type 2 diabetes. Design The study was conducted on 114 individuals with newly-diagnosed T2D and 118 healthy matched controls, aged 20-80 years. Fasting blood glucose and insulin were measured by the enzymatic method and enzyme-linked immunosorbent assay, respectively. Insulin-resistance was calculated by homeostasis model assessment estimated-insulin resistance (HOMA-IR). The gene polymorphism was examined by polymerase chain reaction-restriction fragment length polymorphism. Results There are significant differences between IRS1 Gly971Arg polymorphism and studied individuals (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|