Central administration of peptide and small molecule MC4 receptor antagonists induce hyperphagia in mice and attenuate cytokine-induced anorexia
| Autor: | Alan C. Foster, Stacy Markison, Nick Ling, Margaret Joppa, Kathleen Gogas, Caroline W. Chen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Agonist
medicine.medical_specialty Cachexia Physiology medicine.drug_class Ratón medicine.medical_treatment Anorexia Hyperphagia Biology Peptides Cyclic Biochemistry Mice Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Animals Melanocyte-Stimulating Hormones digestive oral and skin physiology Antagonist medicine.disease Melanocortin 4 receptor Cytokine Receptor Melanocortin Type 4 Female medicine.symptom Melanocortin hormones hormone substitutes and hormone antagonists Interleukin-1 |
| Zdroj: | Peptides. 26:2294-2301 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/j.peptides.2005.03.002 |
| Popis: | We investigated the effect of melanocortin 4 receptor (MC4) antagonists on food intake in mice. Food intake during the light phase was significantly increased by ICV administration of mixed MC3/MC4 antagonists (AgRP and SHU9119) or MC4 selective antagonist peptide [(Cyclo (1–5)[Suc– d –Nal–Arg–Trp–Lys]NH 2 ] (MBP10) and the small molecule antagonists THP and NBI-30. Both mixed and selective antagonists significantly reversed anorexia induced by ICV administration of the MC4 agonist (c (1–6) HfRWK-NH 2 ) and the cytokine IL-1β. These findings provide pharmacological evidence that the MC4 receptor mediates the effects of melanocortin agonists and antagonists on food intake in mice, and support the idea that selective small molecule MC4 antagonists may be useful as therapeutics for cachexia. |
| Databáze: | OpenAIRE |
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