Application of chiral triazole-substituted iodoarenes in the enantioselective construction of spirooxazolines

Autor:	Ayham H. Abazid, Boris J. Nachtsheim
Rok vydání:	2021
Předmět:	Metals and Alloys Triazole Enantioselective synthesis General Chemistry Combinatorial chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Yield (chemistry) Materials Chemistry Ceramics and Composites
Zdroj:	Chemical communications (Cambridge, England). 57(70)
ISSN:	1364-548X
Popis:	A catalytic highly enantioselective synthesis of spirooxazolines is presented. Starting from readily available 2-naphthol-substituted benzamides and using catalytic amounts of a chiral triazole-substituted iodoarene catalyst, a variety of spirooxazolines can be isolated through an enantioselective oxidative dearomatization in up to 92% yield and 97% ee. The further synthetic utility of the optically enriched spirooxazolines was examined providing a corresponding 2-naphthalenole and an oxepin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f83e08f7e2200776d5378061ef4324 https://pubmed.ncbi.nlm.nih.gov/34382967 Zobrazit plný text záznamu