Filter Cone Spray Ionization Coupled to a Portable MS System: Application to On-Site Forensic Evidence and Environmental Sample Analysis
| Autor: | Christina R. Wilson-Frank, Alessandra M. Bruno, Alyssa J Gasa, Zachary E. Lawton, Ashley R. Stelmack, Angelica Traub, Christopher C. Mulligan, Shahnaz Mukta, William L. Fatigante |
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| Rok vydání: | 2020 |
| Předmět: |
Consumables
Chemistry business.industry Sample (material) 010401 analytical chemistry 010402 general chemistry Mass spectrometry 01 natural sciences 0104 chemical sciences law.invention Trace evidence Structural Biology Filter (video) law Ionization Process engineering business Spectroscopy Filtration Ambient ionization |
| Zdroj: | Journal of the American Society for Mass Spectrometry. 31(2) |
| ISSN: | 1879-1123 |
| Popis: | The complexity of field-borne sample matrices and the instrumental constraints of portable mass spectrometers (MS) often necessitate that preparative steps are added prior to ambient MS methods when operated on-site, but the corresponding decrease in throughput and experimental simplicity can make field operation impractical. To this end, we report a modified ambient MS method, filter cone spray ionization (FCSI), specifically designed for simple, yet robust, processing of bulk forensic evidence and environmental samples using a fieldable MS system. This paper-crafted source utilizes low-cost laboratory consumables to produce a conical structure that serves as a disposable, spray-based ionization source. Integrated extraction and filtration capabilities mitigate sample heterogeneity and carryover concerns and expedite sample processing, as characterized through the analysis of a variety of authentic forensic evidence types (e.g., abused pharma tablets, counterfeit/adulterated tablets, crystal-based drugs, synthetic marijuana, toxicological specimens) and contaminated soil samples. The data presented herein suggests that the FCSI-MS design could prove robust to the rigors of field-borne, bulk sample screening, overcoming the inefficiencies of other ambient MS methods for these sample classes. Novel applications of FCSI-MS are also examined, such as the coupling to trace evidence vacuum filtration media. |
| Databáze: | OpenAIRE |
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