Effect of a 12-week endurance training program on force transfer and membrane integrity proteins in lean, obese, and type 2 diabetic subjects
Autor: | Hermann Zbinden-Foncea, Henning T. Langer, Hugo Marambio, Keith Baar, Sebastian Jannas-Vela |
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Rok vydání: | 2020 |
Předmět: |
Male
Physiology Training intervention Medical Physiology Type 2 diabetes endurance exercise 030204 cardiovascular system & hematology lcsh:Physiology 0302 clinical medicine force transfer proteins Medicine Original Research type II diabetes lcsh:QP1-981 biology Diabetes Skeletal Middle Aged Exercise Therapy Endurance Training Membrane integrity medicine.anatomical_structure Muscle Female Dystrophin Type 2 Ankyrins medicine.medical_specialty Clinical Sciences dystrophin 03 medical and health sciences Thinness Endurance training Clinical Research Physiology (medical) Internal medicine Diabetes Mellitus Humans Obesity Muscle Strength Muscle Skeletal Metabolic and endocrine Nutrition obese business.industry Skeletal muscle Membrane Proteins Ankyrin Repeat Protein medicine.disease Endocrinology Diabetes Mellitus Type 2 biology.protein business 030217 neurology & neurosurgery |
Zdroj: | Physiological reports, vol 8, iss 9 Physiological Reports, Vol 8, Iss 9, Pp n/a-n/a (2020) Physiological Reports |
Popis: | The mechanisms accounting for the loss of muscle function with obesity and type 2 diabetes are likely the result of a combination of neural and muscular factors. One muscular factor that is important, yet has received little attention, is the protein machinery involved in longitudinal and lateral force transmission. The purpose of this study was to compare the levels of force transfer and membrane integrity proteins before and after a 12‐week endurance training program in lean, obese, and obese type 2 diabetic adults. Nineteen sedentary subjects (male = 8 and female = 11) were divided into three groups: Lean (n = 7; 50.3 ± 4.1 y; 69.1 ± 7.2 kg); Obese (n = 6; 49.8 ± 4.1 y; 92.9 ± 19.5 kg); and Obese with type 2 diabetes (n = 6; 51.5 ± 7.9 years; 88.9 ± 15.1 kg). Participants trained 150 min/week between 55% and 75% of VO2max for 12 weeks. Skeletal muscle biopsies were taken before and after the training intervention. Baseline dystrophin and muscle LIM protein levels were higher (~50% p A 12‐week endurance training regimen has a relatively small effect on the levels of force transfer and membrane integrity proteins of lean, obese and type 2 diabetic individuals. Only dystrophin and muscle ankyrin repeat protein were decreased after training in lean and obese individuals, respectively. |
Databáze: | OpenAIRE |
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