Effect of a 12-week endurance training program on force transfer and membrane integrity proteins in lean, obese, and type 2 diabetic subjects

Autor: Hermann Zbinden-Foncea, Henning T. Langer, Hugo Marambio, Keith Baar, Sebastian Jannas-Vela
Rok vydání: 2020
Předmět:
Male
Physiology
Training intervention
Medical Physiology
Type 2 diabetes
endurance exercise
030204 cardiovascular system & hematology
lcsh:Physiology
0302 clinical medicine
force transfer proteins
Medicine
Original Research
type II diabetes
lcsh:QP1-981
biology
Diabetes
Skeletal
Middle Aged
Exercise Therapy
Endurance Training
Membrane integrity
medicine.anatomical_structure
Muscle
Female
Dystrophin
Type 2
Ankyrins
medicine.medical_specialty
Clinical Sciences
dystrophin
03 medical and health sciences
Thinness
Endurance training
Clinical Research
Physiology (medical)
Internal medicine
Diabetes Mellitus
Humans
Obesity
Muscle Strength
Muscle
Skeletal
Metabolic and endocrine
Nutrition
obese
business.industry
Skeletal muscle
Membrane Proteins
Ankyrin Repeat Protein
medicine.disease
Endocrinology
Diabetes Mellitus
Type 2
biology.protein
business
030217 neurology & neurosurgery
Zdroj: Physiological reports, vol 8, iss 9
Physiological Reports, Vol 8, Iss 9, Pp n/a-n/a (2020)
Physiological Reports
Popis: The mechanisms accounting for the loss of muscle function with obesity and type 2 diabetes are likely the result of a combination of neural and muscular factors. One muscular factor that is important, yet has received little attention, is the protein machinery involved in longitudinal and lateral force transmission. The purpose of this study was to compare the levels of force transfer and membrane integrity proteins before and after a 12‐week endurance training program in lean, obese, and obese type 2 diabetic adults. Nineteen sedentary subjects (male = 8 and female = 11) were divided into three groups: Lean (n = 7; 50.3 ± 4.1 y; 69.1 ± 7.2 kg); Obese (n = 6; 49.8 ± 4.1 y; 92.9 ± 19.5 kg); and Obese with type 2 diabetes (n = 6; 51.5 ± 7.9 years; 88.9 ± 15.1 kg). Participants trained 150 min/week between 55% and 75% of VO2max for 12 weeks. Skeletal muscle biopsies were taken before and after the training intervention. Baseline dystrophin and muscle LIM protein levels were higher (~50% p
A 12‐week endurance training regimen has a relatively small effect on the levels of force transfer and membrane integrity proteins of lean, obese and type 2 diabetic individuals. Only dystrophin and muscle ankyrin repeat protein were decreased after training in lean and obese individuals, respectively.
Databáze: OpenAIRE
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