Prognostic Indicators for Ebola Patient Survival

Autor: Aaron C. Brault, Jay Achar, John D. Klena, Johanna S. Salzer, Jessica A. Belser, Matthew J. Maenner, Joyce Foday, Alhajie Turay, Christin H. Goodman, Laura K. McMullan, César G. Albariño, Jonathan S. Towner, Eric Bergeron, Angela J. Sanchez, Samuel J. Crowe, Alison Jane Basile, Solomon S Kuah, David Q.-H. Wang, Dianna M. Blau, Michel Van Herp, Christopher D. Paddock, Mike Flint, Bobbie R. Erickson, Darren Hertz, Veerle Hermans, Tara K. Sealy, Brandy J. Russell, Scott W. Bearden, Grazia Caleo, Gbessay Saffa, Megan Coffee, Aridth Gibbons, Stuart T. Nichol, Barbara Knust, Brian R. Amman, Shelley Campbell
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Epidemiology
viruses
lcsh:Medicine
Disease
medicine.disease_cause
Ebola virus
0302 clinical medicine
030212 general & internal medicine
Young adult
virus diseases
Middle Aged
Ebolavirus
Hospitalization
Infectious Diseases
Population Surveillance
Ebola
Female
Medical emergency
Viral load
hemorrhagic fever
Adult
Microbiology (medical)
medicine.medical_specialty
Adolescent
Prognostic Indicators for Ebola Patient Survival
Ebola virus disease
survival
Sierra leone
Sierra Leone
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
mental disorders
medicine
Humans
lcsh:RC109-216
Symptom onset
Mortality
Cycle threshold
business.industry
Research
lcsh:R
Patient survival
Hemorrhagic Fever
Ebola

medicine.disease
zoonoses
030104 developmental biology
Emergency medicine
prognosis
business
Zdroj: Emerging Infectious Diseases, Vol 22, Iss 2, Pp 217-223 (2016)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: Odds of survival were greatest when first Ebola virus–positive blood sample collected had low viral load.
To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus–positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus–positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of
Databáze: OpenAIRE
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