Current and Emerging Therapeutic Approaches in HCV-Related Mixed Cryoglobulinemia
| Autor: | Laura Troiani, F. Dammacco, L. Sansonno, Domenico Sansonno, Felicia Anna Tucci |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Chemokine
Hepacivirus medicine.medical_treatment Hepatitis C virus Alpha interferon medicine.disease_cause Antiviral Agents Biochemistry Antibodies Monoclonal Murine-Derived chemistry.chemical_compound Rheumatoid Factor Ribavirin Drug Discovery Humans Medicine Rheumatoid factor Enzyme Inhibitors Pharmacology B-Lymphocytes biology business.industry Organic Chemistry Antibodies Monoclonal Immunotherapy Hepatitis C Chronic Oligonucleotides Antisense biology.organism_classification Cryoglobulinemia Immunoglobulin M chemistry Immunology biology.protein Molecular Medicine Interferons Rituximab business Viral load Signal Transduction |
| Zdroj: | Current Medicinal Chemistry. 15:117-126 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/092986708783330610 |
| Popis: | Recognition of hepatitis C virus (HCV) as an etiological factor in mixed cryoglobulinemia (MC) has dramatically changed our point of view in its treatment. Emphasis is placed on abatement and clearance of viral load and deletion of clonal expansions of IgM molecules with rheumatoid factor activity-synthesising B cells. The purpose of this review is to discuss the underlying scientific rationale and results of clinical studies of new treatment approaches to MC, with a focus on cell-depleting therapies and chemokine blockade. Additional antiviral agents directed to several phases of HCV life cycle acting with different or alternate mechanisms are proposed with the goal to enhance response rates more broadly suitable for MC patients with vasculitis and peripheral neuropathies. The majority of the available data on these new treatment approaches stems from open-label studies, but controlled trials are under way. Therapy directed against chemokines and/or cytokines represents an interesting and promising future target. |
| Databáze: | OpenAIRE |
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