The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage

Autor: Federica Patrizio, Roberta Ceci, Ilenia Bazzucchi, Massimo Sacchetti, Stefania Sabatini, Luigi Di Luigi, Francesco Felici, Paolo Sgrò, Guglielmo Duranti
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
electromyography
Muscle Fibers
Skeletal

Isometric exercise
Electromyography
Antioxidants
0302 clinical medicine
muscle damage
Myofibrils
Elbow Joint
Eccentric
Creatine Kinase
Nutrition and Dietetics
Cross-Over Studies
biology
medicine.diagnostic_test
Cardiology
Arm
Quercetin
medicine.symptom
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
lcsh:TX341-641
Placebo
Article
03 medical and health sciences
Young Adult
Double-Blind Method
Internal medicine
Isometric Contraction
medicine
Humans
Muscle Strength
Muscle
Skeletal

Exercise
muscle weakness
030109 nutrition & dietetics
L-Lactate Dehydrogenase
business.industry
Muscle weakness
Resistance Training
030229 sport sciences
Myalgia
Crossover study
Dietary Supplements
biology.protein
Creatine kinase
Myofibril
business
Food Science
Zdroj: Nutrients
Volume 11
Issue 1
Nutrients, Vol 11, Iss 1, p 205 (2019)
ISSN: 2072-6643
Popis: The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 ±
3.1 years) ingested either Q (1000 mg/day) or placebo (PLA) for 14 days using a randomized, double-blind, crossover study design. Participants completed a comprehensive neuromuscular (NM) evaluation before, during and after an eccentric protocol able to induce a severe muscle damage (10 sets of 10 maximal lengthening contractions). The NM evaluation comprised maximal voluntary isometric contraction (MVIC) and force&ndash
velocity relationship assessments with simultaneous recording of electromyographic signals (EMG) from the elbow flexor muscles. Soreness, resting arm angle, arm circumference, plasma creatine kinase (CK) and lactate dehydrogenase (LDH) were also assessed. Q supplementation significantly increased the isometric strength recorded during MVIC compared to baseline (+4.7%, p <
0.05). Moreover, the torque and muscle fiber conduction velocity (MFCV) decay recorded during the eccentric exercise was significant lower in Q compared to PLA. Immediately after the EEIMD, isometric strength, the force&ndash
velocity relationship and MFCV were significantly lower when participants were given PLA rather than Q. Fourteen days of Q supplementation seems able to attenuate the severity of muscle weakness caused by eccentric-induced myofibrillar disruption and sarcolemmal action potential propagation impairment.
Databáze: OpenAIRE