The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage
Autor: | Federica Patrizio, Roberta Ceci, Ilenia Bazzucchi, Massimo Sacchetti, Stefania Sabatini, Luigi Di Luigi, Francesco Felici, Paolo Sgrò, Guglielmo Duranti |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male electromyography Muscle Fibers Skeletal Isometric exercise Electromyography Antioxidants 0302 clinical medicine muscle damage Myofibrils Elbow Joint Eccentric Creatine Kinase Nutrition and Dietetics Cross-Over Studies biology medicine.diagnostic_test Cardiology Arm Quercetin medicine.symptom lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty lcsh:TX341-641 Placebo Article 03 medical and health sciences Young Adult Double-Blind Method Internal medicine Isometric Contraction medicine Humans Muscle Strength Muscle Skeletal Exercise muscle weakness 030109 nutrition & dietetics L-Lactate Dehydrogenase business.industry Muscle weakness Resistance Training 030229 sport sciences Myalgia Crossover study Dietary Supplements biology.protein Creatine kinase Myofibril business Food Science |
Zdroj: | Nutrients Volume 11 Issue 1 Nutrients, Vol 11, Iss 1, p 205 (2019) |
ISSN: | 2072-6643 |
Popis: | The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 ± 3.1 years) ingested either Q (1000 mg/day) or placebo (PLA) for 14 days using a randomized, double-blind, crossover study design. Participants completed a comprehensive neuromuscular (NM) evaluation before, during and after an eccentric protocol able to induce a severe muscle damage (10 sets of 10 maximal lengthening contractions). The NM evaluation comprised maximal voluntary isometric contraction (MVIC) and force&ndash velocity relationship assessments with simultaneous recording of electromyographic signals (EMG) from the elbow flexor muscles. Soreness, resting arm angle, arm circumference, plasma creatine kinase (CK) and lactate dehydrogenase (LDH) were also assessed. Q supplementation significantly increased the isometric strength recorded during MVIC compared to baseline (+4.7%, p < 0.05). Moreover, the torque and muscle fiber conduction velocity (MFCV) decay recorded during the eccentric exercise was significant lower in Q compared to PLA. Immediately after the EEIMD, isometric strength, the force&ndash velocity relationship and MFCV were significantly lower when participants were given PLA rather than Q. Fourteen days of Q supplementation seems able to attenuate the severity of muscle weakness caused by eccentric-induced myofibrillar disruption and sarcolemmal action potential propagation impairment. |
Databáze: | OpenAIRE |
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