Are peptide conjugates the golden therapy against obesity?

Autor: Timo D. Müller, M. H. Tschöp, Maximilian Kleinert, Sara J. Brandt
Rok vydání: 2018
Předmět:
Zdroj: Journal of Endocrinology
J. Endocrinol. 238, R109-R119 (2018)
The Journal of Endocrinology
ISSN: 1479-6805
0022-0795
DOI: 10.1530/joe-18-0264
Popis: Obesity is a worldwide pandemic, which can be fatal for the most extremely affected individuals. Lifestyle interventions such as diet and exercise are largely ineffective and current anti-obesity medications offer little in the way of significant or sustained weight loss. Bariatric surgery is effective, but largely restricted to only a small subset of extremely obese patients. While the hormonal factors mediating sustained weight loss and remission of diabetes by bariatric surgery remain elusive, a new class of polypharmacological drugs shows potential to shrink the gap in efficacy between a surgery and pharmacology. In essence, this new class of drugs combines the beneficial effects of several independent hormones into a single entity, thereby combining their metabolic efficacy to improve systems metabolism. Such unimolecular drugs include single molecules with agonism at the receptors for glucagon, glucagon-like peptide 1 and the glucose-dependent insulinotropic polypeptide. In preclinical studies, these specially tailored multiagonists outperform both their mono-agonist components and current best in class anti-obesity medications. While clinical trials and vigorous safety analyses are ongoing, these drugs are poised to have a transformative effect in anti-obesity therapy and might hopefully lead the way to a new era in weight-loss pharmacology.
Databáze: OpenAIRE
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