Strongyloidiasis in Southern Alicante (Spain): Comparative Retrospective Study of Autochthonous and Imported Cases
| Autor: | María Navarro Cots, Emilio Borrajo Brunete, María García López, Belén Martínez López, Jara Llenas-García, Ana Lucas Dato, Inmaculada González Cuello, José María Saugar, José Antonio Ruiz-Maciá, Elisa García-Vazquez, Joan Gregori Colomé, María Isabel Pacheco-Tenza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty lcsh:Medicine Asymptomatic Article Strongyloides stercoralis Serology ivermectin Internal medicine Eosinophilia Epidemiology medicine Immunology and Allergy strongyloidiasis Molecular Biology Ivermectin immunosuppression General Immunology and Microbiology biology business.industry immigrants lcsh:R Retrospective cohort study Odds ratio medicine.disease biology.organism_classification Infectious Diseases Strongyloidiasis Strongyloides medicine.symptom business eosinophilia Immunosuppression |
| Zdroj: | Pathogens Volume 9 Issue 8 Pathogens, Vol 9, Iss 601, p 601 (2020) Repisalud Instituto de Salud Carlos III (ISCIII) |
| ISSN: | 2076-0817 |
| DOI: | 10.3390/pathogens9080601 |
| Popis: | Background: Strongyloidiasis is a parasitic disease with global prevalence. In Spain, autochthonous cases are concentrated in the Mediterranean basin. We aimed to analyze clinical and epidemiological characteristics of Strongyloides stercoralis infection in Vega Baja del Segura (Spain), comparing autochthonous versus imported cases. Methods: Observational retrospective study of all strongyloidiasis cases from January 2009 to January 2019. Cases were diagnosed by stool larvae visualization, positive culture, PCR, Strongyloides serology, and/or compatible histology. Results: We included 36 patients (21 men) with a mean age of 60.8 years ± 17.6 15 cases were autochthonous and 21 imported 80.9% from Latin America. Autochthonous cases were associated with older age (mean 71.3 vs 53.3 years p = 0.002), male sex (odds ratio (OR) 5.33 95% confidence interval (CI) 1.15&ndash 24.68 p = 0.041), and agricultural activity (OR 13.5 95% CI 2.4&ndash 73.7 p = 0.002). Fourteen were asymptomatic, three autochthonous cases presented with hyperinfection syndrome, and two patients died. There was no difference between autochthonous versus imported origin in eosinophilia at diagnosis (93.3% vs 75% p = 0.207), treatment received, or clinical response (85.7% vs 88.9% cured p = 1). Conclusion: In our region, imported strongyloidiasis coexists with autochthonous cases, which are mainly in older male farmers who are diagnosed at more advanced stages. Systematic screening programs are needed. |
| Databáze: | OpenAIRE |
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