Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker
| Autor: | Slobodan M. Todorovic, Adam Meyenburg, Vesna Jevtovic-Todorovic |
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| Rok vydání: | 2002 |
| Předmět: |
Hot Temperature
Pharmacology Rats Sprague-Dawley Calcium Channels T-Type Physical Stimulation Antinociceptive Agents medicine Pain perception Animals Channel blocker Molecular Biology Pain Measurement Mibefradil Analgesics Dose-Response Relationship Drug Chemistry General Neuroscience T-type calcium channel Calcium Channel Blockers Sensory neuron Rats Nociception medicine.anatomical_structure Anesthesia Systemic administration Female Neurology (clinical) Injections Intraperitoneal Developmental Biology medicine.drug |
| Zdroj: | Brain research. 951(2) |
| ISSN: | 0006-8993 |
| Popis: | Voltage-gated Ca(2+) channels play a crucial role in pain perception. We studied the antinociceptive potential of systemically administered mibefradil, a peripherally acting antihypertensive agent and preferential T-type Ca(2+) channel blocker. Systemic injections of mibefradil, in clinically relevant doses, induced mechanical and thermal antinociception in adult rats without compromising their sensorimotor abilities. This suggests that peripherally acting T-type Ca(2+) channel blockers can be useful antinociceptive agents. |
| Databáze: | OpenAIRE |
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