Impact of surgical resection rate on survival in gastric cancer: nationwide study
| Autor: | Magnus Nilsson, C. H. Kung, Jonas Johansson, Jakob Hedberg, Mats Lindblad, C. Jestin Hannan, Gustav Linder |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Surgical resection medicine.medical_specialty Adenocarcinoma Sensitivity and Specificity Gastroenterology Resection 03 medical and health sciences 0302 clinical medicine Risk Factors Stomach Neoplasms Internal medicine Overall survival Humans Medicine Registries Age of Onset Neoplasm Staging Proportional Hazards Models Geographic difference Sweden Entire population business.industry Proportional hazards model gastric cancer Kirurgi Hazard ratio Cancer General Medicine medicine.disease Survival Rate 030220 oncology & carcinogenesis excision geographic difference Original Article Female Surgery 030211 gastroenterology & hepatology Neoplasm Grading business |
| Zdroj: | BJS Open |
| ISSN: | 2474-9842 |
| DOI: | 10.1093/bjsopen/zraa017 |
| Popis: | Background There are marked geographical variations in the proportion of patients undergoing resection for gastric cancer. This study investigated the impact of resection rate on survival. Methods All patients with potentially curable gastric cancer between 2006 and 2017 were identified from the Swedish National Register of Oesophageal and Gastric Cancer. The annual resection rate was calculated for each county per year. Resection rates in all counties for all years were grouped into tertiles and classified as low, intermediate or high. Survival was analysed using the Cox proportional hazards model. Results A total of 3465 patients were diagnosed with potentially curable gastric cancer, and 1934 (55.8 per cent) were resected. Resection rates in the low (1261 patients), intermediate (1141) and high (1063) tertiles were 0–50.0, 50.1–62.5 and 62.6–100 per cent respectively. The multivariable Cox analysis revealed better survival for patients diagnosed in counties during years with an intermediate versus low resection rate (hazard ratio (HR) 0.81, 95 per cent c.i. 0.74 to 0.90; P There is large geographical variation in the proportion of patients undergoing curative resection of gastric cancer in Sweden. This study found that a higher proportion of patients undergoing curative resection is of survival benefit for the whole population of patients with gastric cancer. Regional variations influence outcome |
| Databáze: | OpenAIRE |
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