Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA
| Autor: | Robabeh Ghergherechi, Siamak Shiva, Haleh Behbod |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty endocrine system diseases Diabetic ketoacidosis Adolescent Cross-sectional study Endocrinology Diabetes and Metabolism medicine.medical_treatment Drug Resistance Down-Regulation Type 2 diabetes Severity of Illness Index Diabetic Ketoacidosis Endocrinology Child Development Diabetes mellitus Severity of illness Medicine Humans Hypoglycemic Agents Insulin Insulin-Like Growth Factor I Child Type 1 diabetes business.industry nutritional and metabolic diseases Infant medicine.disease Hospitals Pediatric Up-Regulation Clinical trial Cross-Sectional Studies Diabetes Mellitus Type 1 Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 26(9-10) |
| ISSN: | 2191-0251 |
| Popis: | BACKGROUND AND OBJECTIVE The issue of insulin-like growth factor 1 (IGF-1) and diabetes in adults and type 2 diabetes has been well investigated. A few studies have investigated the serum IGF-1 level at the onset of type 1 diabetes mellitus (T1DM) in children. In the present study, we investigated the IGF-1 level of T1DM children before and after insulin therapy. SUBJECTS AND METHODS Between August 2011 and October 2012, 62 children with newly diagnosed T1DM were recruited. Serum IGF-1 levels were compared before and 1 month after insulin therapy between diabetic ketoacidosis (DKA) and non-DKA patients. RESULTS Thirty-one patients without DKA (18 girls and 13 boys, mean age 8.8 ± 3.01 years) and 31 patients with DKA (18 girls and 13 boys, mean age 8.3 ± 3.7 years) were studied. The mean IGF-1 in the DKA group was lower than that in the non-DKA group; however, this difference was not statistically significant (p=0.10). Serum IGF-1 levels increased significantly 1 month after insulin therapy in both the DKA (p |
| Databáze: | OpenAIRE |
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