Plasma Creatine Kinetics After Ingestion of Microencapsulated Creatine Monohydrate with Enhanced Stability in Aqueous Solutions
| Autor: | Giuseppe De Vito, Brendan Egan, Alessandro Scotto di Palumbo, Sinead B. Bleiel, Robert Kent, Michelle Hone |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Protein Hydrolysates Drug Compounding Kinetics Biological Availability Diosgenin Creatine Eating Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Drug Stability milk protein plasma kinetics Humans Ingestion Pharmacology (medical) Nutrition and Dietetics Aqueous solution Chromatography Milk protein Phytosterols 030229 sport sciences Milk Proteins Maltodextrin Healthy Volunteers Bioavailability Solutions 030104 developmental biology bioavailability creatine microencapsulation supplementation chemistry Creatine Monohydrate Food Science |
| Zdroj: | Journal of Dietary Supplements. 14:433-445 |
| ISSN: | 1939-022X 1939-0211 |
| DOI: | 10.1080/19390211.2016.1267060 |
| Popis: | Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencapsulated CRE (3-g creatine monohydrate; n = 5) conditions. Experimental conditions involved ingestion of the samples in a 70-mL ready-to-drink format. CRE was delivered in a novel microencapsulation matrix material consisting entirely of hydrolyzed milk protein. Three hours after ingestion, plasma creatine concentrations were unchanged during PLA, and averaged ∼45 μM. During CRE, plasma creatine concentration peaked after 30 min at 101.6 ± 14.9 μM (p0.05), representing a 2.3-fold increase over PLA. Thereafter, plasma creatine concentration gradually trended downwards but remained significantly elevated (∼50% above resting levels) 3 hr after ingestion. These results demonstrate that the microencapsulated form of creatine monohydrate reported herein remains bioavailable when delivered in aqueous conditions, and has potential utility in ready-to-drink formulations for creatine supplementation. |
| Databáze: | OpenAIRE |
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