Prospective, observational practice survey of applied skin care and management of cetuximab-related skin reactions: PROSKIN study
| Autor: | Sandro Anchisi, Vera Bühler, Daniel Betticher, Stefanie Pederiva, Roger von Moos, Regina Woelky, Miklos Pless, Marco Dressler, Sacha I. Rothschild, Peter Moosmann, Reinhard Zenhäusern, R. A. Popescu, Markus Borner, Daniel Rauch, Claudia Papet, Antonello Calderoni |
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| Rok vydání: | 2019 |
| Předmět: |
Practice survey
Male 0301 basic medicine Vitamin Cancer Research medicine.medical_specialty Colorectal cancer Skin Cream Cetuximab Acneiform rash 610 Medicine & health Toxicology 03 medical and health sciences chemistry.chemical_compound Antineoplastic Agents Immunological 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) In patient Prospective Studies Observational Pharmacology Skin care Squamous Cell Carcinoma of Head and Neck business.industry Vitamin K 1 Vitamins Middle Aged medicine.disease Skin reactions Management Anti-Bacterial Agents Skin reaction Treatment Outcome 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Original Article Female Observational study Drug Eruptions Colorectal Neoplasms business medicine.drug |
| Zdroj: | Rothschild, Sacha I; Betticher, Daniel; Zenhäusern, Reinhard; Anchisi, Sandro; von Moos, Roger; Pless, Miklos; Moosmann, Peter; Popescu, Razvan A; Calderoni, Antonello; Dressler, Marco; Rauch, Daniel; Pederiva, Stefanie; Woelky, Regina; Papet, Claudia; Bühler, Vera; Borner, Markus (2019). Prospective, observational practice survey of applied skin care and management of cetuximab-related skin reactions: PROSKIN study. Cancer chemotherapy and pharmacology, 84(4), pp. 881-889. Springer 10.1007/s00280-019-03927-x Cancer Chemotherapy and Pharmacology |
| ISSN: | 1432-0843 0344-5704 |
| Popis: | PURPOSE The study aimed to investigate strategies to prevent and treat cetuximab-induced skin reactions and their perceived effectiveness in patients with metastatic colorectal cancer (mCRC) and recurrent/metastatic squamous cell cancer of the head and neck (SCCHN). METHODS This open-label, prospective observational study was conducted in Switzerland. RESULTS A total of 125 patients were included (n = 91 mCRC, n = 34 SCCHN; mean age 63.3 years; 73.6% males). The frequency of acneiform rash grade ≥ 2 increased from 12.6% at week 2 to 21.7% at week 16. The proportion of patients who reported no skin reaction decreased from 75.6% at week 2 to 43.3% at week 16. The most frequently used skin products at any time of observation were moisturizing (77.6%), lipid-regenerating (56.8%) or urea-containing products (52%), systemic antibiotics (49.6%), and vitamin K1 cream (43.2%). There was no clear effectiveness pattern for all product classes: in given patients, either the product showed no effect at all or a moderate/strong effect, consistently over time. CONCLUSIONS A great variety of low-cost general skin care products were commonly used. According to physician's preference, systemic antibiotics and vitamin K1 cream are an appropriate approach to prevent or treat cetuximab-related skin toxicity. |
| Databáze: | OpenAIRE |
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