A double-edged sword: Prolonged detection of SARS-COV-2 in patients receiving cancer directed therapy
| Autor: | Samuel Pan, Claire Brieva, Winston Wong, Susan Whittier, Maura Abbott, Gary K. Schwartz, Ilenia Pellicciotta, Gulam A. Manji, Jianhua Hu, Eldad A. Hod, Karen Gambina, Michael May |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) New York Recommendations Asymptomatic Article Serology 03 medical and health sciences 0302 clinical medicine Internal medicine Neoplasms Medicine Humans Prospective Studies Cancer Retrospective Studies biology business.industry SARS-CoV-2 COVID-19 Retrospective cohort study Hematology Middle Aged medicine.disease Prognosis Combined Modality Therapy Detection 030104 developmental biology PCR Oncology 030220 oncology & carcinogenesis Prolonged biology.protein Female Sarcoma Antibody medicine.symptom business Viral load |
| Zdroj: | Seminars in Oncology |
| ISSN: | 0093-7754 |
| DOI: | 10.1053/j.seminoncol.2020.11.001 |
| Popis: | Introduction: SARS-CoV-2 (S-2) infection duration and its impact on patients with cancer and mild to moderate COVID-19 undergoing cancer-directed therapy (CDT), especially in the underserved population, is not well described. We conducted a retrospective study to analyze S-2 positive (+) patients on CDT to describe the S-2 duration and its impact on CDT. Methods:Two hundred ninety-nine patients with cancer were tested with nasopharyngeal (NP) S-2 PCR assay at Columbia University Medical Irving Center (CUIMC), a Minority-NCI Community Oncology site, of which 77 (26%) tested positive. We retrospectively analyzed 26 S-2 (+) patients with mild-to-moderate COVID-19 receiving CDT who consented to the study. NP PCR was repeated every 1 to 2 weeks until 2 successive negative (−) PCRs were obtained prior to restarting CDT. Time to 2 (−) PCR and serology results were recorded. Cycling thresholds (Ct) were obtained for S-2 specific targets and represented an indirect measure of viral load. Results: Demographics of N = 26 patients are: Hispanic (N = 17, 65%), Black (N = 1, 4%), White (N = 7, 27%), and undeclared (N = 1, 4%). Among the tumor histologies represented, gastrointestinal (N = 9, 35%), breast (N = 5, 19%), and sarcoma (N = 3, 12%) were most common. Median time to 2 (−) PCR was 32 days. Twenty patients required greater than 14 days to achieve 2 sequential (−) swabs. CDT was delayed in 21 patients (81%) of whom three experienced disease progression, likely attributed to an interruption in CDT, which was delayed by a mean of 53 days. Interestingly, nine (41%) patients had Ct values greater than 34 for the pan SARS target and seven (32%) patients had Ct values greater than 34 for the SARS-COV-2 target. Sixteen of 16 patients on CDT, tested positive for IgG antibodies at the time of consent, despite protracted viral detectability by NP PCR. Conclusion: Patients receiving CDT appear to have prolonged detectable S-2 by PCR, which can lead to interruption of CDT and POD in patients. We believe and recommend that patients with asymptomatic to mild COVID-19 and aggressive malignancies are at greatest risk for cancer related morbidity and mortality due to CDT cessation and should be considered for continued CDT without interruption. Ct values and serology testing are tools that can help identify those patients on CDT who may be at greatest risk of worsening COVID-19 or of spreading S-2. |
| Databáze: | OpenAIRE |
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