Treatment and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial
| Autor: | Dirce Maria Sigulem, Vinícius Montenegro Torres, Maria Claret Costa Monteiro Hadler, Maria de Fátima Costa Alves |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Anemia Folic Acid Deficiency Placebo Gastroenterology Drug Administration Schedule Ferrous law.invention Placebos chemistry.chemical_compound Hemoglobins Folic Acid Randomized controlled trial law Internal medicine Medicine Nutritional Epidemiology Humans Ferrous Compounds Sulfate Epidemiologia Nutricional Anemia Iron-Deficiency business.industry Incidence (epidemiology) Public Health Environmental and Occupational Health Infant Sulfato Ferroso Child Day Care Centers medicine.disease Surgery Clinical trial Ácido Fólico Vitamin B 12 Treatment Outcome chemistry Ferrous Sulfate Child Preschool Dietary Supplements Hematinics Creches Female Hemoglobin business Epidemiologic Methods Brazil |
| Zdroj: | Cadernos de Saúde Pública v.24 suppl.2 2008 Cadernos de Saúde Pública Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ Cadernos de Saúde Pública, Volume: 24 Supplement 2, Pages: s259-s271, Published: 2008 |
| ISSN: | 1678-4464 |
| Popis: | The objective of this study was to assess the prevalence of anemia and the therapeutic and prophylactic response to ferrous sulfate and folic acid. A double-blind, randomized, controlled clinical trial was conducted with 196 children 6 to 24 months of age enrolled in municipal daycare centers in Goiânia, Goiás State, Brazil. The children were assigned to two treatment groups that received a daily dose (5 times a week) of either 4.2mg/kg/day of ferrous sulfate + folic acid (50µg) or 4.2mg/kg/day of ferrous sulfate + folic acid placebo. One of the prevention groups received 1.4mg/kg/day of ferrous sulfate + folic acid (50µg/day) and the other 1.4mg/kg/day of ferrous sulfate + folic acid placebo. Supplementation lasted approximately three months. Baseline anemia prevalence was 56.1% (95%CI: 48.9-63.1). After treatment, anemia prevalence in the folic acid group (14%) was lower than in the placebo group (34.9%) (p = 0.02). After prophylaxis in the non-anemic children, the incidence of anemia did not differ between the groups, but there was an increase in hemoglobin level in the folic acid group (p = 0.003). Iron plus folic acid was effective for the treatment of anemia and improvement of hemoglobin level in non-anemic children. Avaliar a prevalência de anemia e a resposta terapêutica e profilática do sulfato ferroso e ácido fólico. Realizou-se um ensaio clínico controlado randomizado, duplo-cego, com 196 crianças de 6 a 24 meses, dos Centros Municipais de Educação Infantil de Goiânia, Goiás, Brasil. As crianças foram alocadas em dois grupos de tratamento que receberam dose diária (5x/semana) com 4,2mg/kg/dia de sulfato ferroso + ácido fólico (50µg) ou 4,2mg/kg/dia de sulfato ferroso + placebo de ácido fólico. Um dos grupos de prevenção recebeu 1,4 mg/kg/dia de sulfato ferroso + ácido fólico (50µg/dia) e o outro 1,4mg/kg/dia de sulfato ferroso + placebo de ácido fólico. A suplementação durou cerca de três meses. A prevalência de anemia inicial foi de 56,1% (IC95%: 48,9-63,1). Após o tratamento, a prevalência de anemia no grupo ácido fólico (14%) foi menor que no grupo placebo (34,9%; p = 0,02). Após profilaxia dos não anêmicos, a incidência de anemia não diferiu entre os grupos, porém, houve incremento da hemoglobina no grupo ácido fólico (p = 0,003). O ferro associado com ácido fólico foi eficaz no tratamento da anemia e na melhoria da hemoglobina nos não anêmicos. |
| Databáze: | OpenAIRE |
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