Recent progress in the study of the Rheb family GTPases
| Autor: | S. Zahra Bathaie, Valerie Fong, Jeffrey J. Heard, Fuyuhiko Tamanoi |
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| Rok vydání: | 2014 |
| Předmět: |
Protein Structure
Rheb GTPase Biochemistry & Molecular Biology Mouse study 1.1 Normal biological development and functioning Medical Physiology Mutagenesis (molecular biology technique) mTORC1 GTPase Mechanistic Target of Rapamycin Complex 1 Cardiovascular System Article Underpinning research Lysosome Mitophagy medicine Animals Humans Monomeric GTP-Binding Proteins Cancer biology Effector TOR Serine-Threonine Kinases Mutants Structure Cell Biology Protein Structure Tertiary Cell biology Brain Disorders medicine.anatomical_structure Multiprotein Complexes biology.protein Biochemistry and Cell Biology Lysosomes Tertiary RHEB |
| Zdroj: | Cellular signalling, vol 26, iss 9 |
| Popis: | In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have expanded our understanding of residues that affect Rheb GTP/GDP bound ratios, effector protein interactions, and stimulation of mTORC1 signaling. Analysis of cancer genome databases has revealed that several human carcinomas contain activating mutations of the protein. Rheb’s role in activating mTORC1 signaling at the lysosome in response to stimuli has been further elucidated. Rheb has also been suggested to play roles in other cellular pathways including mitophagy and peroxisomal ROS response. A number of studies in mice have demonstrated the importance of Rheb in development, as well as in a variety of functions including cardiac protection and myelination. We conclude with a discussion of future prospects in the study of Rheb family GTPases. |
| Databáze: | OpenAIRE |
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